Skip to Content
MilliporeSigma

Skip To

SML1003

Sigma-Aldrich

K145 hydrochloride

≥98% (HPLC)

Synonym(s):

3-(2-Amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione hydrochloride

Sign Into View Organizational & Contract Pricing

Select a Size

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C18H24N2O3S · HCl
CAS Number:
Molecular Weight:
384.92
UNSPSC Code:
12352200
NACRES:
NA.77
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

S1\C(=C/CCc2ccc(cc2)OCCCC)\C(=O)N(C1=O)CCN.Cl

InChI

1S/C18H24N2O3S.ClH/c1-2-3-13-23-15-9-7-14(8-10-15)5-4-6-16-17(21)20(12-11-19)18(22)24-16;/h6-10H,2-5,11-13,19H2,1H3;1H/b16-6-;

InChI key

HADFDMGQKBGVAV-NKBLJONXSA-N

General description

K145 hydrochloride (3-(2-Amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione) is an analog of sphingosine.

Application

K145 hydrochloride has been used in the analysis of apoptosis.

Biochem/physiol Actions

It has the ability to prevent leukemia cell growth in vitro.
K145 (3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione) is a selective inhibitor of sphingosine kinase-2 (SphK2) and an anticancer agent. K145 selectively inhibited SphK2 in a dose-dependent manner with an IC50 of 4.30 +/- 0.06 μM with no inhibition of SphK1 at concentrations up to 10 μM. K145 significantly suppressed the growth of U937 tumors in nude mice and the growth of JC tumor cells in BALB/c mice.
K145 is a selective inhibitor of sphingosine kinase-2 and an anticancer agent.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service