Name: TB5
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₄BrNOS

CAS Number:

948841-07-4

Molecular Weight:

336.25

MDL number:

MFCD30718167

UNSPSC Code:

12352200

NACRES:

NA.77

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

yellow to orange

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN(C)C(C=C1)=CC=C1/C=C/C(C2=CC=C(Br)S2)=O

InChI

1S/C15H14BrNOS/c1-17(2)12-6-3-11(4-7-12)5-8-13(18)14-9-10-15(16)19-14/h3-10H,1-2H3/b8-5+

InChI key

PTLDLBSWTKNYCY-VMPITWQZSA-N

Biochem/physiol Actions

Potent and selective reversible inhibitor of monoamine oxidase B (MAOB)

TB5 is a potent and selective reversible inhibitor of monoamine oxidase B (MAOB) with a Ki value of 110 nM. A reversible inhibitor should have an advantage over irreversible inhibitors such as selegiline in limiting side effects. Parallel artificial membrane permeation (PAMPA) assays indicated TB5 should be able to cross the blood–brain barrier. TB5 was found nontoxic to cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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