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About This Item

Empirical Formula (Hill Notation):
C27H23FClNO4
CAS Number:
Molecular Weight:
479.93
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

faint yellow to dark orange

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

FC(C=CC=C1)=C1CC2=C([N+](CC3)=CC4=C2C=CC(OC)=C4OC)C5=C3C=C(OCO6)C6=C5.[Cl-]

InChI key

RPHFGOXVJGNJJH-UHFFFAOYSA-M

Biochem/physiol Actions

KRN2 is a specific and potent inhibitor of nuclear factor of activated T cells 5 (NFAT5) that inhibits formation of NF-κB p65-DNA complexes. KRN2 suppresses migration of Fibroblast-like synoviocytes stimulated with TGF-β. KRN2 ameliorates experimental arthritis in mice.
KRN2 or 13-(2-fluorobenzyl)-berberine is a berberine derivative that effectively blocks the invasiveness of fibroblast-like synoviocytes (FLS). It is stable and orally bioavailable. It suppresses the production of proinflammatory cytokines to ameliorate arthritis severity.
specific and potent inhibitor of nuclear factor of activated T cells 5 (NFAT5) that inhibits formation of NF-κB p65-DNA complexes

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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