Name: QX77
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₃ClN₂O₂

CAS Number:

1798331-92-6

Molecular Weight:

300.74

MDL number:

MFCD31657441

UNSPSC Code:

12352200

NACRES:

NA.77

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

Clc1cc2c(cc1)NC(=CO2)c3ccc(cc3)NC(=O)C

InChI

1S/C16H13ClN2O2/c1-10(20)18-13-5-2-11(3-6-13)15-9-21-16-8-12(17)4-7-14(16)19-15/h2-9,19H,1H3,(H,18,20)

InChI key

FVNBPTNXXWCRJJ-UHFFFAOYSA-N

Biochem/physiol Actions

Chaperone-mediated autophagy (CMA) activator that rescues LAMP2A lysosomal localization in cystinotic cells and reduces toxic α-syn accumulation in PD astrocytes.

QX77 is a chaperone-mediated autophagy (CMA) activator derived from the atypical retinoid AR7 that activates CMA by antagonizing retinoic acid receptor-α (RARα) signaling. QX77 rescues defective trafficking & lysosomal localization of the CMA receptor LAMP2A in cystinotic Ctns^-/- MEFs and CTNS-KO human proximal tubule cells (PTCs) by restoring Rab11 expression and Rab11-positive vesicles trafficking to the level seen in wild-type cells (20 μM, 48 hrs). CMA activation by QX77 treatment (20 μM, 5 days) also significantly reduces toxic α-synuclein (α-syn) accumulation in PD patients iPSCs-derived astrocytes with LRRK2 G2019S mutation.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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