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T2379

Sigma-Aldrich

Tubocurarine hydrochloride pentahydrate

≥97%

Synonym(s):

(+)-Tubocurarine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C37H41ClN2O6 · HCl · 5H2O
CAS Number:
6989-98-6
Molecular Weight:
771.72
MDL number:
MFCD00150157
UNSPSC Code:
12352200
PubChem Substance ID:
24900034
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

200

assay

≥97%

solubility

H2O: soluble 50 mg/ml, with heating as required, clear to slightly hazy, colorless to yellow
ethanol: soluble
methanol: soluble

storage temp.

2-8°C

SMILES string

O.O.O.O.O.Cl.[Cl-].COc1cc2CCN(C)[C@H]3Cc4ccc(Oc5c(O)c(OC)cc6CC[N+](C)(C)[C@H](Cc7ccc(O)c(Oc1cc23)c7)c56)cc4

InChI

1S/C37H40N2O6.2ClH.5H2O/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;;;;;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H;5*1H2/t28-,29+;;;;;;;/m0......./s1

InChI key

WMIZITXEJNQAQK-GGDSLZADSA-N

Gene Information

human ... CHRNA1(1134), CHRNB1(1140), CHRND(1144), CHRNE(1145), CHRNG(1146)

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assay

≥98%

assay

98%

assay

97%

assay

98%

solubility

95% ethanol: soluble 50 mg/mL, clear to very slightly hazy, colorless to yellow, diethyl ether: soluble, propylene glycol: soluble, water: insoluble, benzene: soluble, toluene: soluble, isopropanol: soluble

solubility

methanol: soluble 1 g/10 mL, clear, colorless to very faintly yellow

solubility

toluene: soluble 2.5%, clear, yellow

solubility

methanol: soluble 50 mg/mL, clear to slightly hazy, colorless to yellow

mp

158-160 °C (lit.)

mp

177-179 °C (lit.)

mp

74-77 °C (lit.)

mp

228-231 °C (lit.)

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

Application

Tubocurarine hydrochloride pentahydrate has been used as a acetylcholinesterase inhibitor (Ach) inhibitor in myotubes,[1] muscle[2] and as neuromuscular junction blocker in zebra fish embryos.[3]

Biochem/physiol Actions

Tubocurarine is a muscle relaxant[4] and a nicotinic acetylcholine receptor antagonist.[5] It can induce neuromuscular blocking.[6]

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Tubocurarine hydrochloride pentahydrate is soluble in water at 50 mg/ml (with heat as required) and yields a clear to slightly hazy, colorless to yellow solution. It is also soluble in methanol and ethanol.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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