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X4879

Sigma-Aldrich

Xaliproden hydrochloride

≥97% (HPLC), solid

Synonym(s):

1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]pyridine hydrochloride, SR-57746A

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About This Item

Empirical Formula (Hill Notation):
C24H22F3N · HCl
CAS Number:
90494-79-4
Molecular Weight:
417.89
MDL number:
MFCD00896209
UNSPSC Code:
12352200
PubChem Substance ID:
329830807
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

assay

≥97% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: ≥5 mg/mL

originator

Sanofi Aventis

storage temp.

2-8°C

SMILES string

Cl.FC(F)(F)c1cccc(c1)C2=CCN(CCc3ccc4ccccc4c3)CC2

InChI

1S/C24H22F3N.ClH/c25-24(26,27)23-7-3-6-22(17-23)20-11-14-28(15-12-20)13-10-18-8-9-19-4-1-2-5-21(19)16-18;/h1-9,11,16-17H,10,12-15H2;1H

InChI key

WVHBEIJGAINUBW-UHFFFAOYSA-N

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Show Differences

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Xaliproden hydrochloride ≥97% (HPLC), solid

X4879

Xaliproden hydrochloride

Dapiprazole hydrochloride ≥98% (HPLC)

SML1610

Dapiprazole hydrochloride

CMPD101 hydrochloride ≥98% (HPLC)

SML2784

CMPD101 hydrochloride

CP-94,253 dihydrochloride ≥98% (HPLC)

SML0588

CP-94,253 dihydrochloride

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

solubility

DMSO: ≥5 mg/mL

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 15 mg/mL, clear

originator

Sanofi Aventis

originator

-

originator

-

originator

-

Biochem/physiol Actions

5-HT1A serotonin receptor agonist; neuroprotectant

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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    Certificates of Analysis (COA)

    Lot/Batch Number
    029K4605V
    029K4605
    028K46081
    028K4608

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    Marc Porzner et al.
    Expert opinion on investigational drugs, 18(11), 1765-1772 (2009-10-10)
    Neurodegenerative disorders such as Alzheimer's disease or amyotrophic lateral sclerosis as well as peripheral neuropathies are difficult to treat due to a limited range of effective drugs. Neurotrophic growth factors promote neuronal survival and differentiation and could hence be interesting
    G S Ruigt et al.
    Neuroscience letters, 203(1), 9-12 (1996-01-12)
    A co-culture system of intact rat dorsal root ganglia (DRG) with Schwann cells was used to evaluate the potential neurotrophic activity of SR 57746A. Neuritogenesis from DRG was measured with an image analysis system following exposure to different concentrations of
    A Appert-Collin et al.
    International journal of immunopathology and pharmacology, 18(2), 233-244 (2005-05-13)
    Neurotrophic growth factors are involved in cell survival. However, natural growth factors have a very limited therapeutic use because of their short half-life. In the present study, we investigated the mechanism of action of a non-peptidic neurotrophic drug, Xaliproden, a
    Xaliproden lessens oxaliplatin-mediated neuropathy.
    Ed Susman
    The Lancet. Oncology, 7(4), 288-288 (2006-04-08)
    J Fournier et al.
    The Journal of pharmacy and pharmacology, 50(3), 323-327 (1998-05-26)
    SR 57746A (1-(2beta-naphthylethyl)-4-(3-trifluoromethylphenyl)-1,2,5,6 -tetrahydropyridine hydrochloride) is a neuroprotective compound which potentiates nerve-growth factor (NGF)-induced differentiation in PC12 cells. We have evaluated the interaction of SR 57746A with the other members of the neurotrophin family in this cell-line. In contrast with
    View All Related Papers

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