Improved synthesis of a DNA-dependent protein kinase inhibitor IC86621.

Improved synthesis of a DNA-dependent protein kinase inhibitor IC86621.

Archives of pharmacal research (2012-05-04)

Girish Chandra, Varughese Alexander, Hyuk Woo Lee, Lak Shin Jeong

ABSTRACT

An improved synthesis of DNA-dependent protein kinase inhibitor, IC86621 is described. This developed method provides an easy access to this simple molecule by using amination, acetylation and Fries rearrangement reactions.

MATERIALS

Product Number

Brand

Product Description

101079

Sigma-Aldrich

3-Bromophenol, 98%

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