- Impact of copper-catalyzed cross-coupling reactions in natural product synthesis: the emergence of new retrosynthetic paradigms.
Impact of copper-catalyzed cross-coupling reactions in natural product synthesis: the emergence of new retrosynthetic paradigms.
Natural product reports (2013-10-25)
Gwilherm Evano, Cédric Theunissen, Alexandre Pradal
PMID24154547
ABSTRACT
Copper-catalyzed Ullmann-Goldberg-type cross-coupling reactions have undergone nothing short of a renaissance over the last decade and an impressive number of procedures are now available for the formation of C-N, C-O and C-S bonds with remarkable efficiencies and surgical precision. These reactions have been recently integrated into natural product synthesis, which clearly resulted in the emergence of new retrosynthetic paradigms and bond disconnections. The impact of copper-catalyzed cross-coupling reactions in natural product synthesis will be overviewed in this article with an emphasis on the evolution of strategies due to copper catalysis, mostly by comparison with alternative tactics and their relative efficiencies.
MATERIALS
Product Number
Brand
Product Description
Copper, tube, 100mm, outside diameter 1.2mm, inside diameter 0.56mm, wall thickness 0.32mm, as drawn, 99.9%
Copper, tube, 1000mm, outside diameter 2.5mm, inside diameter 1.9mm, wall thickness 0.3mm, as drawn, 99.9%
Copper, sphere, 100pcs, diameter 1.0mm, precision sphere grade 200
Copper, tube, 100mm, outside diameter 0.95mm, inside diameter 0.29mm, wall thickness 0.33mm, as drawn, 99.9%
Copper, rod, 500mm, diameter 9.5mm, hard, 99.9%
Copper, tube, 100mm, outside diameter 0.65mm, inside diameter 0.21mm, wall thickness 0.22mm, as drawn, 99.9%
Copper, rod, 100mm, diameter 2.0mm, as drawn, 99.99+%
Copper, tube, 1000mm, outside diameter 1.75mm, inside diameter 0.33mm, wall thickness 0.71mm, as drawn, 99.9%
Copper, rod, 50mm, diameter 5.0mm, as drawn, 99.999%
Copper, tube, 1000mm, outside diameter 0.25mm, inside diameter 0.05mm, wall thickness 0.1mm, as drawn, 99.9%
Copper, tube, 100mm, outside diameter 1.5mm, inside diameter 0.6mm, wall thickness 0.45mm, as drawn, 99.9%
Copper, tube, 1000mm, outside diameter 3.0mm, inside diameter 1.2mm, wall thickness 0.9mm, as drawn, 99.9%
Copper, tube, 1000mm, outside diameter 6.35mm, inside diameter 4.93mm, wall thickness 0.71mm, as drawn, 99.9%
Copper, tube, 1000mm, outside diameter 3.5mm, inside diameter 1.56mm, wall thickness 0.97mm, as drawn, 99.9%
Copper, tube, 100mm, outside diameter 0.25mm, inside diameter 0.05mm, wall thickness 0.1mm, as drawn, 99.9%
Copper, tube, 100mm, outside diameter 10.4mm, inside diameter 10mm, wall thickness 0.2mm, as drawn, 99.9%
Copper, tube, 1000mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, as drawn, 99.9%
Copper, tube, 1000mm, outside diameter 4.0mm, inside diameter 3.2mm, wall thickness 0.4mm, as drawn, 99.9%
Copper, tube, 100mm, outside diameter 4.0mm, inside diameter 3.2mm, wall thickness 0.4mm, as drawn, 99.9%
Copper, tube, 500mm, outside diameter 0.95mm, inside diameter 0.29mm, wall thickness 0.33mm, as drawn, 99.9%
Copper - O.F.H.C., foil, 50mm disks, thickness 0.7mm, half hard, 99.95+%
Copper - O.F.H.C., foil, 1m coil, thickness 0.025mm, hard, 99.95+%
Copper - O.F.H.C., foil, 1m coil, thickness 0.05mm, hard, 99.95+%
Copper - O.F.H.C., foil, 15mm disks, thickness 0.025mm, hard, 99.95+%
Copper - O.F.H.C., foil, 10m coil, thickness 0.1mm, half hard, 99.95+%
Copper - O.F.H.C., foil, 5m coil, thickness 0.05mm, hard, 99.95+%
Copper - O.F.H.C., foil, 50mm disks, thickness 0.025mm, hard, 99.95+%
Copper - O.F.H.C., foil, 1m coil, thickness 0.1mm, coil width 100mm, hard, 99.95+%
Copper - O.F.H.C., foil, 15mm disks, thickness 0.1mm, hard, 99.95+%
Copper, tube, 200mm, outside diameter 1.75mm, inside diameter 0.33mm, wall thickness 0.71mm, as drawn, 99.9%