Synthesis of deuterium-labelled isotopomer of deferasirox.

Synthesis of deuterium-labelled isotopomer of deferasirox.

Journal of labelled compounds & radiopharmaceuticals (2015-02-19)

Freddy H Havaldar, Bhushan Vasant Dabholkar, Ganesh Baban Mule, Suhas Kulkarni

ABSTRACT

A d4 -labeled isotopomer of deferasirox was synthesized as internal standard for use in a LC/mass spectroscopy (MS)/MS method developed for the simultaneous quantitative determination of deferasirox in human serum. d4 -deferasirox was synthesized from d8 -toluene.

MATERIALS

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471399

Sigma-Aldrich

Toluene-d₈, 99 atom % D, contains 0.03 % (v/v) TMS

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233382

Sigma-Aldrich

Toluene-d₈, "100%", 99.96 atom % D

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151998

Sigma-Aldrich

Toluene-d₈, 99 atom % D

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570710

Sigma-Aldrich

Toluene-d₈, anhydrous, 99.6 atom % D

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434388

Sigma-Aldrich

Toluene-d₈, 99.6 atom % D

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