- SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells.
SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells.
Scientific reports (2017-03-23)
Mourad Ferdaoussi, Jianyang Fu, Xiaoqing Dai, Jocelyn E Manning Fox, Kunimasa Suzuki, Nancy Smith, Gregory Plummer, Patrick E MacDonald
PMID28325894
ABSTRACT
Insulin secretion from pancreatic ß cells is a multistep process that requires the coordination of exocytotic proteins that integrate diverse signals. These include signals derived from metabolic control of post-translational SUMOylation and depolarization-induced rises in intracellular Ca
MATERIALS