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MilliporeSigma

LMNA

lamin A/C

Synonyms:
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1
Species:
Human LMNA (4000), Mouse Lmna (16905), Rat Lmna (60374), Zebrafish lmna (195815), cow LMNA (404144), Horse LMNA (100057663), domestic cat LMNA (101086199), dog LMNA (480124), chicken LMNA (415464), domestic guinea pig Lmna (100735212) ...More
UniProtKB ID:
P02545, B4DI32, D3DVB0, E7EUI9, P02546, Q5TCJ2, Q5TCJ3, Q969I8
Gene ID:
  • Human(4000) Summary: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
  • Mouse(16905) lamin A
  • Rat(60374) lamin A/C
  • Zebrafish(195815) lamin A
  • cow(404144) lamin A/C
  • Horse(100057663) lamin A/C
  • domestic cat(101086199) lamin A/C
  • dog(480124) lamin A/C
  • chicken(415464) lamin A/C
  • domestic guinea pig(100735212) lamin A/C
  • naked mole-rat(101704567) lamin A/C
  • sheep(101107924) lamin A/C

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
MABT330
Anti-Lamin A (mature) Antibody, clone 4A4-A4, clone 4A4-A4, from mouse,
Species Reactivity
human
Application
immunocytochemistry
immunoprecipitation (IP)
western blot
ABT1389
Anti-Phospho Lamin A/C (Ser22), from rabbit,
Species Reactivity
human
Application
inhibition assay
western blot
MABT858
Anti-prelamin A Antibody, clone PL-1C7, clone PL-1C7, from mouse,
Species Reactivity
human, mouse
Application
ELISA
flow cytometry
immunocytochemistry
western blot
MAB3540
Anti-Lamin A Antibody, CT, a.a. 598-611, clone 133A2, clone 133A2, Chemicon®, from mouse,
Species Reactivity
bovine, canine, human, mouse, rat
Application
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
ABT1387
Anti-Phospho-Lamin A/C (Ser404), from rabbit,
Species Reactivity
human
Application
immunofluorescence
inhibition assay
western blot

esiRNA

Product Number
Description
Species
EHU063791
MISSION® esiRNA, targeting human LMNA,
Species
human
EMU056191
MISSION® esiRNA, targeting mouse Lmna,
Species
mouse