MAP3K7
mitogen-activated protein kinase kinase kinase 7
Synonyms:
MEKK7, TAK1, TGF1a
Species:
Human MAP3K7 (6885), Mouse Map3k7 (26409), Rat Map3k7 (313121), Domestic Rabbit MAP3K7 (100343571), naked mole-rat Map3k7 (101718269), domestic guinea pig Map3k7 (100718100), sheep MAP3K7 (101108056), sheep MAP3K7 (100294587), Zebrafish map3k7 (553788), cow MAP3K7 (529146) ...More
UniProtKB ID:
Gene ID:
- Human(6885) Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- Mouse(26409) mitogen-activated protein kinase kinase kinase 7
- Rat(313121) mitogen activated protein kinase kinase kinase 7
- Domestic Rabbit(100343571) mitogen-activated protein kinase kinase kinase 7
- naked mole-rat(101718269) mitogen-activated protein kinase kinase kinase 7
- domestic guinea pig(100718100) mitogen-activated protein kinase kinase kinase 7
- sheep(101108056) mitogen-activated protein kinase kinase kinase 7
- sheep(100294587) mitogen-activated protein kinase kinase kinase 7
- Zebrafish(553788) mitogen activated protein kinase kinase kinase 7
- cow(529146) mitogen-activated protein kinase kinase kinase 7
- Horse(100065841) mitogen-activated protein kinase kinase kinase 7
- domestic cat(101095899) mitogen-activated protein kinase kinase kinase 7
- dog(474996) mitogen-activated protein kinase kinase kinase 7
- chicken(421808) mitogen-activated protein kinase kinase kinase 7
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-TAK1 (pThr184) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-phospho-TAK1 (Ser412) Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human, mouse
Application
western blot
Anti-TAK1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot
western blot
Anti-Phospho-TAK1-T187 antibody produced in rabbit, ,
Species Reactivity
human, mouse
Application
western blot
Anti-TAK1 Antibody, clone 1W2B10, Rabbit Monoclonal, ,
Species Reactivity
mouse
Application
immunoprecipitation (IP)
western blot
western blot
Proteins
Product Number
Description
Species
TAK1-TAB1 fusion Protein, active, 10 µg, Active, N-terminal His6-tagged, recombinant, human TAK1 amino acids 1-303, fused to human TAB1 amino acids 437-end, for use in Kinase Assays.,
Species
human
TAK1-TAB1 (1-303), (437-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human