PTEN
phosphatase and tensin homolog
Synonyms:
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Species:
Human PTEN (5728), Mouse Pten (19211), Rat Pten (50557), fruit fly Pten (43991), domestic cat PTEN (101091813), dog PTEN (403832), chicken PTEN (423675), cow PTEN (540786), sheep PTEN (101119351), domestic guinea pig Pten (100723659)
UniProtKB ID:
Gene ID:
- Human(5728) Summary: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
- Mouse(19211) phosphatase and tensin homolog
- Rat(50557) phosphatase and tensin homolog
- fruit fly(43991) CG5671 gene product from transcript CG5671-RB
- domestic cat(101091813) phosphatase and tensin homolog
- dog(403832) phosphatase and tensin homolog
- chicken(423675) phosphatase and tensin homolog
- cow(540786) phosphatase and tensin homolog
- sheep(101119351) phosphatase and tensin homolog
- domestic guinea pig(100723659) phosphatase and tensin homolog
- naked mole-rat(101714930) phosphatase and tensin homolog
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-PTEN antibody produced in mouse, clone 2G9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
proximity ligation assay
western blot
proximity ligation assay
western blot
Monoclonal Anti-PTEN antibody produced in mouse, clone 3E7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunoprecipitation (IP)
western blot
immunofluorescence
immunoprecipitation (IP)
western blot
Anti-Phospho-PTEN-S380 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-PTEN antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM265, purified immunoglobulin,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-phospho-PTEN (pSer385) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA