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RRM1

ribonucleotide reductase M1

Synonyms:
R1, RIR1, RR1
Species:
UniProtKB ID:
Gene ID:
  • Human(6240) Summary: This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq, Jul 2008]
  • Mouse(20133) ribonucleotide reductase M1
  • Rat(685579) ribonucleotide reductase M1
  • Zebrafish(30740) ribonucleotide reductase M1 polypeptide
  • chicken(419081) ribonucleotide reductase M1
  • domestic cat(101097343) ribonucleotide reductase M1
  • Horse(100053126) ribonucleotide reductase M1
  • dog(476823) ribonucleotide reductase M1
  • Domestic Rabbit(100345823) ribonucleotide reductase M1
  • naked mole-rat(101708047) ribonucleotide reductase M1
  • domestic guinea pig(100728488) ribonucleotide reductase M1
  • cow(505537) ribonucleotide reductase M1
  • sheep(101116171) ribonucleotide reductase M1

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-RRM1 Antibody, clone 4P4U1, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
western blot
Monoclonal Anti-RRM1 antibody produced in mouse, clone 1D6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
western blot
Anti-RRM1 antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP167, affinity isolated antibody,
Species Reactivity
bovine, human, mouse
Application
flow cytometry
immunofluorescence

immunohistochemistry
Anti-RRM1 Antibody, clone 1E20 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, monkey
Application
affinity binding assay
flow cytometry

immunohistochemistry

western blot
Anti-RRM1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry

Small Molecule - Inhibitor

Product Number
Description
Species
Hydroxyurea, Vetec, reagent grade, ≥98%,
Species
human
Hydroxyurea, United States Pharmacopeia (USP) Reference Standard,
Species
human
Hydroxycarbamide, European Pharmacopoeia (EP) Reference Standard,
Species
human
Hydroxycarbamide, British Pharmacopoeia (BP) Reference Standard,
Species
human
Hydroxyurea, 98%, powder,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human RRM1,
Species
human
MISSION® esiRNA, targeting mouse Rrm1,
Species
mouse