SREBF1
sterol regulatory element binding transcription factor 1
Synonyms:
SREBP-1c, SREBP1, bHLHd1
Species:
Human SREBF1 (6720), Mouse Srebf1 (20787), Rat Srebf1 (78968), Zebrafish srebf1 (793274), dog SREBF1 (403475), domestic cat SREBF1 (101087535), Horse SREBF1 (100052283), chicken SREBF1 (373915), naked mole-rat Srebf1 (101705277), domestic guinea pig Srebf1 (100731641) ...More
UniProtKB ID:
Gene ID:
- Human(6720) Summary: This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(20787) sterol regulatory element binding transcription factor 1
- Rat(78968) sterol regulatory element binding transcription factor 1
- Zebrafish(793274) sterol regulatory element binding transcription factor 1
- dog(403475) sterol regulatory element binding transcription factor 1
- domestic cat(101087535) sterol regulatory element binding transcription factor 1
- Horse(100052283) sterol regulatory element binding transcription factor 1
- chicken(373915) sterol regulatory element binding transcription factor 1
- naked mole-rat(101705277) sterol regulatory element binding transcription factor 1
- domestic guinea pig(100731641) sterol regulatory element binding transcription factor 1
- cow(539361) sterol regulatory element binding transcription factor 1
- sheep(100329218) sterol regulatory element binding transcription factor 1
- Goat(100860908) sterol regulatory element binding transcription factor 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-SREBF1 antibody produced in mouse, clone 4B10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Monoclonal Anti-SREBF1 antibody produced in mouse, clone 4C11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-SREBP-1 Antibody, clone 20B12, clone 20B12, from rabbit,
Species Reactivity
human, mouse
Application
western blot
Anti-SREBP-1, from rabbit, purified by affinity chromatography,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-SREBP1 Antibody, clone 2D21 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot