D193

DL-α-Difluoromethylornithine hydrochloride hydrate

≥97% (NMR), solid, polyamine biosynthesis inhibitor

• Sinónimos: 2-(Difluoromethyl)ornithine hydrochloride hydrate, DFMO hydrochloride hydrate, Eflornithine hydrochloride hydrate
• Fórmula empírica (notación de Hill): C₆H₁₂F₂N₂O₂ · xHCl · yH₂O
• CAS Number: 70052-12-9
• Peso molecular: 182.17 (anhydrous free base basis)
• Número MDL: MFCD00242734
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278809
• NACRES: NA.77

Propiedades

• Product Name: DL-α-Difluoromethylornithine hydrochloride hydrate, solid, ≥97% (NMR)
• Nivel de calidad: 100
• Ensayo: ≥97% (NMR)
• Formulario: solid
• color: white
• solubilidad: DMSO: >10 mg/mL; H₂O: >10 mg/mL
• cadena SMILES: O.Cl.NCCCC(N)(C(F)F)C(O)=O
• InChI: 1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9;;/h4H,1-3,9-10H2,(H,11,12);1H;1H2
• Clave InChI: FJPAMFNRCFEGSD-UHFFFAOYSA-N
• Información sobre el gen: human ... ODC1(4953)

Descripción

Descripción general

Difluoromethylornithine is a fluorinated ornithine analog, which acts as a rate-limiting enzyme of polyamine biosynthesis. It is used to treat female facial hirsutism and human African trypanosomiasis. Difluoromethylornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic effects on mammalian cells and tissues.

Aplicación

DL-α-Difluoromethylornithine hydrochloride hydrate has been used to reduce the effects of arginine on cell proliferation. It has also been used to investigate the effect of bisphenol A (BPA) on the migration of an established ovine trophectoderm (oTr1) cell line.

Acciones bioquímicas o fisiológicas

Difluoromethylornithine (Eflornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis.

Inhibits polyamine biosynthesis by selective, irreversible inhibition of ornithine decarboxylase. Chemoprotective agent that blocks angiogenesis.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)