15759

Poloxamer 188

• Synonym(s): Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lutrol F68
• CAS Number: 9003-11-6
• MDL number: MFCD00082049
• UNSPSC Code: 12352104
• NACRES: NA.25

Properties

• form: solid
• Quality Level: 200
• mol wt: ~7680-9510 g/mol
• composition: oxyethylene, 79.9-83.7%
• impurities: ≤0.25% ethylene glycol and diethylene glycol; ≤0.4% total ash; ≤1 ppm ethylene oxide; ≤1.0% water; ≤2 ppm arsenic traces; ≤20 ppm heavy metals; ≤5 ppm dioxan; ≤5 ppm propylene oxide; 50-150 ppm butylhydroxytoluene
• ign. residue: ≤0.30%
• color: APHA: ≤120, 50/50 in CH₃OH
• pH: 5.0-7.5 (100 g/L in H₂O); 6.0-7.5 (25 g/L in H₂O)
• CMC: 0.48 mM
• transition temp: cloud point >100 °C
• HLB: >24
• SMILES string: O2C(C2)C.O1CC1
• InChI: 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2
• InChI key: RVGRUAULSDPKGF-UHFFFAOYSA-N

Description

Application

• Stabilizing Function of P 188 in Dermal Formulations: Examined for its stabilizing effects on industrial concentrates of dermal hesperidin smartCrystals, P 188 contributed to enhancing the long-term stability of the formulations, relevant for dermal therapeutic interventions (Romero et al., 2015).

Biochem/physiol Actions

Poloxamer 188 is widely used as a thickening agent and gel binder.

Other Notes

The Poloxamer 188 grades are poloxamers from the extensive line of block copolymers.

Legal Information

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1