C6506

4-Chloro-DL-phenylalanine

• Sinônimo(s): PCP, PCPA
• Fórmula linear: ClC₆H₄CH₂CH(NH₂)CO₂H
• CAS Number: 7424-00-2
• Peso molecular: 199.63
• Número CE: 231-051-9
• Número MDL: MFCD00002601
• Código UNSPSC: 12352209
• ID de substância PubChem: 24278081
• NACRES: NA.32

Propriedades

• Formulário: solid
• Nível de qualidade: 100
• pontuação do produto alternativo mais ecológico: old score: 2; new score: 1; Find out more about DOZN™ Scoring
• características do produto alternativo mais ecológico: Less Hazardous Chemical Syntheses; Designing Safer Chemicals; Design for Energy Efficiency; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• pf: >240 °C (dec.) (lit.)
• categoria alternativa mais ecológica: , Re-engineered
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: NC(Cc1ccc(Cl)cc1)C(O)=O
• InChI: 1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
• chave InChI: NIGWMJHCCYYCSF-UHFFFAOYSA-N
• Informações sobre genes: human ... TPH1(7166), TPH2(121278)

Descrição

Descrição geral

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles "Less Hazardous Chemical Syntheses", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here to view its DOZN scorecard.

Aplicação

4-Chloro-DL-phenylalanine has been used:

• as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras⁺ male zebrafish
• to induce insomnia in rat models
• used to treat embryos to examine its effect on serotonin
• for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
• to feed flies to explore serotonin effect

Ações bioquímicas/fisiológicas

4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.

Tryptophan hydroxylase inhibitor.

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H301,H317
• Declarações de precaução: P280 - P301 + P310 + P330 - P302 + P352
• Classificações de perigo: Acute Tox. 3 Oral - Skin Sens. 1
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges