C8655

4-Chloro-L-phenylalanine

• Sinônimo(s): L-PCPA
• Fórmula linear: ClC₆H₄CH₂CH(NH₂)CO₂H
• CAS Number: 14173-39-8
• Peso molecular: 199.63
• Beilstein: 2416150
• Número CE: 238-023-5
• Número MDL: MFCD00063065
• Código UNSPSC: 12352209
• eCl@ss: 32160406
• ID de substância PubChem: 24893091
• NACRES: NA.32

Propriedades

• Formulário: powder
• Nível de qualidade: 200
• pf: 263 °C (dec.) (lit.)
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: N[C@@H](Cc1ccc(Cl)cc1)C(O)=O
• InChI: 1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m0/s1
• chave InChI: NIGWMJHCCYYCSF-QMMMGPOBSA-N
• Informações sobre genes: human ... TPH1(7166), TPH2(121278) ; mouse ... TPH1(21990), TPH2(216343) ; rat ... TPH1(24848), TPH2(317675)

Descrição

Aplicação

4-Chloro-L-phenylalanine (L-PCPA) has been used:

• to block serotonin synthesis by inhibiting tryptophan hydroxylase (TPH)
• to study its behavioral and electrographic effects on epileptic senegalese baboon (Papio papio)
• as a substrate for Chromobacterium violaceum phenylalanine hydroxylase
• to incubate sea urchin embryos for immunohistochemistry

Ações bioquímicas/fisiológicas

4-Chloro-L-phenylalanine (L-PCPA) inhibits the synthesis of 5-hydroxytryptamine (5-HT). 4-Chloro-DL-phenylalanine (PCPA) depletes the serotonin levels in the brain by its inhibitory effect on tryptophan hydroxylase (Tph). Studies support the protective effects of PCPA against monocrotaline-induced pulmonary vascular remodeling as well as in lung inflammation.

Tryptophan hydroxylase inhibitor.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Informações de segurança

• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges