P5585

Palmitic acid

BioXtra, ≥99%

• Sinônimo(s): 1-Pentadecanecarboxylic acid, C16:0, Cetylic acid, Hexadecanoic acid, NSC 5030, PamOH
• Fórmula linear: CH₃(CH₂)₁₄COOH
• CAS Number: 57-10-3
• Peso molecular: 256.42
• Beilstein: 607489
• Número CE: 200-312-9
• Número MDL: MFCD00002747
• Código UNSPSC: 12352106
• ID de substância PubChem: 24898674
• NACRES: NA.25

Propriedades

• fonte biológica: plant (vegetable)
• Nível de qualidade: 200
• grau: BioPerformance Certified
• pressão de vapor: 10 mmHg ( 210 °C)
• linha de produto: BioXtra
• Ensaio: ≥99%
• Formulário: powder
• técnica(s): cell culture | mammalian: suitable
• Impurezas: ≤0.0005% Phosphorus (P); ≤0.1% Insoluble matter
• resíduo de ignição: ≤0.1%
• p.e.: 271.5 °C/100 mmHg (lit.)
• pf: 61-62.5 °C (lit.)
• solubilidade: chloroform: 0.5 M, clear, colorless
• densidade: 0.852 g/mL at 25 °C (lit.)
• traços de ânion: chloride (Cl^-): ≤0.05%; sulfate (SO₄^2-): ≤0.05%
• traços de cátion: Al: ≤0.005%; Ca: ≤0.0005%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Mg: ≤0.0005%; NH₄⁺: ≤0.05%; Na: ≤0.05%; Pb: ≤0.001%; Zn: ≤0.0005%
• grupo funcional: carboxylic acid
• tipo de lipídio: saturated FAs
• Condições de expedição: ambient
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: CCCCCCCCCCCCCCCC(O)=O
• InChI: 1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)
• chave InChI: IPCSVZSSVZVIGE-UHFFFAOYSA-N
• Informações sobre genes: human ... FABP2(2169), FABP3(2170), FABP4(2167), FABP5(2171)

Descrição

Aplicação

Palmitic acid has been used:

• as a medium supplement in chorionic villous tissue culture form placenta
• as a component of hormone pellet for implantation in mice ovary
• for inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1

Ações bioquímicas/fisiológicas

Palmitic acid (PA) is a component of membrane phospholipids (PL) and adipose triacylglycerols (TAG). Elevated levels of palmitic acid contributes to the pathophysiology of atherosclerosis, type 2 diabetes mellitus, neurodegenerative diseases, obesity and cancer. PA promotes apoptosis in the endothelial cell by modulating the p38 mitogen-activated protein kinase (MAPK) pathway and favors expression of TNF-α and reactive oxygen species accumulation. PA promotes interleukin 8 (IL-8) synthesis in hepatocytes contributing to hepatic inflammation. PA by interacting with toll-like receptor 4 (TLR4) induces inflammatory injury in cardiomyoctes.

Palmitic acid is a straight-chain 16-carbon fatty acid. Diets rich in palmitic acid, along with lauric and myristic acids, are associated with increased serum levels of low-density lipoprotein cholesterol. Palmitic acid is the first fatty acid produced by lipogenesis. It is a negative regulator of acetyl-CoA carboxylase (ACC) and is implicated in fatty acid-induced insulin resistance.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): nwg
• Ponto de fulgor (°F): 235.4 °F
• Ponto de fulgor (°C): 113 °C
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves