SRP2131

LXR, α, ligand binding domain, GST tagged human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

• Sinônimo(s): LXR-a, LXRA, RLD-1
• Código UNSPSC: 12352202
• NACRES: NA.26

Propriedades

• fonte biológica: human
• recombinante: expressed in E. coli
• Ensaio: ≥80% (SDS-PAGE)
• Formulário: frozen liquid
• peso molecular: ~53.3 kDa
• embalagem: pkg of 10 μg
• concentração: 500 μg/mL
• cor: clear colorless
• nº de adesão NCBI: NM_005693
• nº de adesão UniProt: Q13133
• Condições de expedição: dry ice
• temperatura de armazenamento: −70°C
• Informações sobre genes: human ... NR1H3(10062)

Descrição

Ações bioquímicas/fisiológicas

Liver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes of LXRs, LXRα and LXRβ. LXRα is preferentially expressed in liver, small intestine, kidney and spleen. In contrast, LXRβ expression is ubiquitous. The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system. Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function. LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes, including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP). LXRα is thought to play a major role in the control of cholesterol catabolism by stimulating the expression of cholesterol 7-α-hydroxylase (CYP7A1), the rate limiting enzyme of bile acid synthesis.

forma física

Clear and colorless frozen liquid solution

Nota de preparo

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable