234524

O-Phenyl chlorothionoformate

99%

• Synonym(s): Phenyl thionochloroformate
• Linear Formula: ClC(S)OC₆H₅
• CAS Number: 1005-56-7
• Molecular Weight: 172.63
• Beilstein: 774830
• EC Number: 213-736-4
• MDL number: MFCD00004920
• UNSPSC Code: 12352100
• PubChem Substance ID: 24854046
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: 99%
• form: liquid
• refractive index: n20/D 1.581 (lit.)
• bp: 81-83 °C/6 mmHg (lit.)
• density: 1.248 g/mL at 25 °C (lit.)
• functional group: chloro; phenoxy
• SMILES string: ClC(=S)Oc1ccccc1
• InChI: 1S/C7H5ClOS/c8-7(10)9-6-4-2-1-3-5-6/h1-5H
• InChI key: KOSYAAIZOGNATQ-UHFFFAOYSA-N

Description

Application

O-Phenyl chlorothionoformate has been used in:

• stereodirected synthesis of optically active, (−)-mintlactone
• synthesis of peptide α-thioesters having a variety of C-terminal amino acids
• synthesis of scyllo-inositol derivatives
• thionocarbonylation of unprotected thymine nucleosides
• preparation of phenoxythiocarbonyl esters of protected ribonucleosides

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H314
• Precautionary Statements: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Hazard Classifications: Skin Corr. 1B
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 3
• Flash Point(F): 177.8 °F - closed cup
• Flash Point(C): 81 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves