238090

1-Bromo-4-iodobenzene

98%

• Synonym(s): 4-Bromo-1-iodobenzene, 4-Bromoiodobenzene, 4-Iodo-1-bromobenzene, 4-Iodophenyl bromide, p-Bromophenyl iodide, p-Iodobromobenzene
• Linear Formula: BrC₆H₄I
• CAS Number: 589-87-7
• Molecular Weight: 282.90
• Beilstein: 1904545
• EC Number: 209-662-7
• MDL number: MFCD00001051
• UNSPSC Code: 12352100
• PubChem Substance ID: 24854290
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: 98%
• form: solid
• bp: 120-122 °C/14 mmHg (lit.)
• mp: 89-91 °C (lit.)
• functional group: bromo; iodo
• SMILES string: Brc1ccc(I)cc1
• InChI: 1S/C6H4BrI/c7-5-1-3-6(8)4-2-5/h1-4H
• InChI key: UCCUXODGPMAHRL-UHFFFAOYSA-N

Description

General description

Vapour pressure as a function of temperature for 1-bromo-4-iodobenzene has been studied using a diaphragm manometer and torsion mass-loss effusion.

Application

1-Bromo-4-iodobenzene has been employed:

• as reagent for in situ desilylation and coupling of silylated alkynes
• as starting reagent in the total syntheses of ent-conduramine A and ent-7-deoxypancratistatin (alkaloids)
• as substrate in copper-free Sonogashira coupling in aqueous acetone
• in synthesis of β,β,dibromostyrenes

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319
• Precautionary Statements: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves