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284785

Sigma-Aldrich

(S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid

98%

Synonym(s):

Naproxen, (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid

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1 MG
₹36,696.00

About This Item

Linear Formula:
CH3OC10H6CH(CH3)CO2H
CAS Number:
22204-53-1
Molecular Weight:
230.26
Beilstein:
3591068
EC Number:
244-838-7
MDL number:
MFCD00010500
UNSPSC Code:
12352005
PubChem Substance ID:
24857178
NACRES:
NA.22

₹36,696.00

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Quality Level

200

Assay

98%

optical activity

[α]25/D +66°, c = 1 in chloroform

mp

152-154 °C (lit.)

functional group

carboxylic acid

SMILES string

COc1ccc2cc(ccc2c1)[C@H](C)C(O)=O

InChI

1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1

InChI key

CMWTZPSULFXXJA-VIFPVBQESA-N

Gene Information

human ... MAPK14(1432), PTGS1(5742), PTGS2(5743)
rat ... Alox5(25290), Ptgs1(24693)

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1 of 4

This Item
SLW718242SLW718342SLW718234
Pyrex® Mortar 300 mL

SLW718247

Pyrex® Mortar

Pyrex® Mortar 120 mL

SLW718242

Pyrex® Mortar

Pyrex® Pestle rough finish, L 110 mm

SLW718342

Pyrex® Pestle

Pyrex® Mortar 100 mL

SLW718234

Pyrex® Mortar

manufacturer/tradename

718247, SciLabware

manufacturer/tradename

718242, SciLabware

manufacturer/tradename

718342, SciLabware

manufacturer/tradename

718234, SciLabware

capacity

300 mL

capacity

120 mL

capacity

-

capacity

100 mL

H

90 mm

H

75 mm

H

-

H

60 mm

O.D.

120 mm

O.D.

100 mm

O.D.

-

O.D.

80 mm

General description

(S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid is a nonsteroidal anti-inflammatory molecule (NSAID). The (S)-enantiomer is 30 times more active than the (R)-enantiomer.[1][2]

Application

(S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid can be used as a chiral ligand in the synthesis of organotin (IV) carboxylate metal complexes.[3][4]

Biochem/physiol Actions

Non-selective cyclooxygenase (COX-1 and COX-2) inhibitor.

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
MKCN6736
MKCM9228
MKCK3959
MKCB0438V
MKBZ0096V

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Xiang-Sheng Zhang et al.
Journal of neurosurgery, 121(1), 42-54 (2014-04-15)
OBJECT.: Aneurysmal subarachnoid hemorrhage (SAH) causes devastating rates of mortality and morbidity. Accumulating studies indicate that early brain injury (EBI) greatly contributes to poor outcomes after SAH and that oxidative stress plays an important role in the development of EBI
Robert G Fassett et al.
Marine drugs, 9(3), 447-465 (2011-05-11)
Astaxanthin is a xanthophyll carotenoid present in microalgae, fungi, complex plants, seafood, flamingos and quail. It is an antioxidant with anti-inflammatory properties and as such has potential as a therapeutic agent in atherosclerotic cardiovascular disease. Synthetic forms of astaxanthin have
Robert G Fassett et al.
Molecules (Basel, Switzerland), 17(2), 2030-2048 (2012-02-22)
Oxidative stress and inflammation are established processes contributing to cardiovascular disease caused by atherosclerosis. However, antioxidant therapies tested in cardiovascular disease such as vitamin E, C and β-carotene have proved unsuccessful at reducing cardiovascular events and mortality. Although these outcomes
Jian Li et al.
Biotechnology advances, 29(6), 568-574 (2011-04-19)
Although natural sources have long been exploited for astaxanthin production, it is still uncertain if natural astaxanthin can be produced at lower cost than that of synthetic astaxanthin or not. In order to give a comprehensive cost analysis of astaxanthin
Jian-Ping Yuan et al.
Molecular nutrition & food research, 55(1), 150-165 (2011-01-06)
The ketocarotenoid astaxanthin can be found in the microalgae Haematococcus pluvialis, Chlorella zofingiensis, and Chlorococcum sp., and the red yeast Phaffia rhodozyma. The microalga H. pluvialis has the highest capacity to accumulate astaxanthin up to 4-5% of cell dry weight.
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