361518

1-Hydroxypyrene

98%

• Synonym(s): 1-Pyrenol
• Empirical Formula (Hill Notation): C₁₆H₁₀O
• CAS Number: 5315-79-7
• Molecular Weight: 218.25
• MDL number: MFCD00044543
• UNSPSC Code: 12352100
• PubChem Substance ID: 24862229
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 98%
• mp: 179-182 °C (lit.)
• SMILES string: Oc1ccc2ccc3cccc4ccc1c2c34
• InChI: 1S/C16H10O/c17-14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9,17H
• InChI key: BIJNHUAPTJVVNQ-UHFFFAOYSA-N

Description

General description

1-Hydroxypyrene, as a urinary metabolite, is a marker of polycyclic aromatic hydrocarbons (PAH) exposure. 1-Hydroxypyrene is an important biomarker of exposure to pyrene.

Application

1-Hydroxypyrene is suitable for use in following studies:

• To investigate the fast detection and quantification of 1-hydroxypyrene in tissue extracts from Nereis diversicolor exposed to sediment-associated pyrene by a simple fluorometric method.
• To investigate the effects of genetic polymorphisms of the cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1) and glutathione S-transferases mu (GSTM1) and theta (GSTT1) on urinary 1-hydroxypyrene and 2-naphthol levels in aircraft maintenance workers.
• To examine the the PAH exposure of cokery workers in an Estonian oil shale processing plant.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves