37640

2,8-Quinolinediol

≥99.0% (HPLC)

• Synonym(s): 2,8-Dihydroxyquinoline
• Empirical Formula (Hill Notation): C₉H₇NO₂
• CAS Number: 15450-76-7
• Molecular Weight: 161.16
• Beilstein: 472906
• MDL number: MFCD00216696
• UNSPSC Code: 12352100
• PubChem Substance ID: 57649744
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: ≥99.0% (HPLC)
• form: powder
• mp: ~290 °C (dec.)
• SMILES string: Oc1ccc2cccc(O)c2n1
• InChI: 1S/C9H7NO2/c11-7-3-1-2-6-4-5-8(12)10-9(6)7/h1-5,11H,(H,10,12)
• InChI key: ZXZKYYHTWHJHFT-UHFFFAOYSA-N

Description

General description

2,8-Quinolinediol is a quinolone derivative. It has been reported as metabolite of 8-hydroxyquinoline-N-oxide in rabbits. Synthesis of 2,8-quinolinediol has been reported. It is reported as one of the six possible forms of 8-hydroxycarbostyril. It has been detected as new UV-absorbing compound (UAC) in cow milk and its structure was elucidated using HRMS and by ¹H, ¹³C and ¹H ×¹³C NMR.It is also known as 8-hydroxycarbostyril or 8-hydroxyquinolin-2(1H)-one.

8-hydroxyquinolin-2(1H)-one has been reported as the tautomeric form of 2,8-quinolinediol. 2,8-Quinolinediol (2,8-Dihydroxyquinoline) has been identified as one of the metabolite of quinolone formed in the culture medium of gram-negative bacteria, Pseudomonas stutzeri.

Application

2,8-Quinolinediol is suitable for use as standard in a study to identify the urinary metabolites for the toxicity related processes and pathogenesis induced by doxorubicin (DOX) to rats by online and off-line LC-MS techniques. It may be used as starting reagent for the preparation of two powerful β2-adrenergic receptor agonists, used for the treatment of asthma:

• Procaterol
• Indacaterol

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves