430471

Poly(D,L-lactide-co-glycolide)

ester terminated, M_w 50,000-75,000

• Synonym(s): Lactel^® B6006-1, PLGA
• Linear Formula: [C₃H₄O₂]_x[C₂H₂O₂]_y
• MDL number: MFCD00131930
• UNSPSC Code: 12162002
• PubChem Substance ID: 24866924
• NACRES: NA.23

Properties

• Quality Level: 100
• form: amorphous
• feed ratio: lactide:glycolide 85:15
• mol wt: M_w 50,000-75,000
• degradation timeframe: <6 months
• viscosity: 0.55-0.75 dL/g, 0.1 % (w/v) in chloroform(25 °C)
• transition temp: T_g 45-50 °C
• solubility: ethyl acetate, chloroform, acetone and THF: soluble
• storage temp.: 2-8°C
• SMILES string: OCC(O)=O.CC(O)C(O)=O
• InChI: 1S/C3H6O3.C2H4O3/c1-2(4)3(5)6;3-1-2(4)5/h2,4H,1H3,(H,5,6);3H,1H2,(H,4,5)
• InChI key: XBBVURRQGJPTHH-UHFFFAOYSA-N

Description

General description

Characteristic properties of ester terminated poly(D,L-lactide-co-glycolide) (PLGA) are in vivo biodegradability, tunable drug release profile and very high encapsulation capacity.

Application

PLGA polymers find uses in the production of biodegradable medical sutures and for controlled drug release. PLGA microspheres have been reported for use in controlled release of human growth hormone. Thin membranes of blended polymers constituting of PLGA/polycaprolactone/β-tricalcium phosphate have been used in guided bone regeneration.

Features and Benefits

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

Physical form

Biocompatible, biodegradable polymer.

Legal Information

Lactel is a registered trademark of Evonik Corp

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves