790404P

18:1 DGS-NTA(Ni)

Avanti Research^™ - A Croda Brand

• Synonym(s): 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (nickel salt); DOGS NTA
• Empirical Formula (Hill Notation): C₅₃H₉₃N₂O₁₅Ni
• CAS Number: 231615-77-3
• Molecular Weight: 1057.00
• MDL number: MFCD00056438
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• description: 1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (nickel salt)
• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 10 mg (790404P-10mg); pkg of 1 × 25 mg (790404P-25mg); pkg of 1 × 5 mg (790404P-5mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• shipped in: dry ice
• storage temp.: −20°C

Description

General description

1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] nitrilotriacetic acid (NTA) (18:1 DGS-NTA(Ni)) is a conjugated phospholipid that contains nickel. NTA chelates with four of the six coordination sites present in nickel ion.

Application

1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (nickel salt) (18:1 DGS-NTA(Ni)) has been used:

• in the preparation of liposomes with porphyrin-phospholipid (PoP) conjugate for protein and peptide binding studies
• in the preparation of nanosize multillamelar vesicles (NMVs) for antigen delivery studies
• as a component of small unilamellar vesicle (SUV) for planar lipid membrane (PM) preparation

Biochem/physiol Actions

1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] nitrilotriacetic acid (NTA) (18:1 DGS-NTA(Ni)) is useful in structural biology especially to bind recombinant histidine tagged proteins. Though useful, being nanoparticulate it has stability problems in biological samples. So NTA-lipid conjugate is majorly used as liposomes or as a coating to nanoparticle. DGS-NTA (Ni) based nanosize multillamelar vesicles (NMVs) are potent vaccine delivery system.

Packaging

5 mL Clear Glass Sealed Ampule (790404P-10mg)

5 mL Clear Glass Sealed Ampule (790404P-25mg)

5 mL Clear Glass Sealed Ampule (790404P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids