857371P

VU0359595

(1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxamide, powder

• Synonym(s): EVJ; VU0359595
• Empirical Formula (Hill Notation): C₂₅H₂₉BrN₄O₂
• CAS Number: 1246303-14-9
• Molecular Weight: 497.43
• MDL number: MFCD22416858
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• Assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 1 mg (857371P-1mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 857371P
• lipid type: bioactive lipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: Brc1cc2[nH][c]([n](c2cc1)C3CCN(CC3)C[C@@H](NC(=O)[C@H]4[C@@H](C4)c5ccccc5)C)=O
• InChI key: JSVNNLRZCJAYTQ-ORYQWCPZSA-N

Description

General description

VU0359595 has been shown to selectively inhibit the PLD1 isoform at nM levels (see data below). **Images added as .gif in folder

Application

VU0359595 has been used as PLD2 (phospholipase D2) inhibitor to quantitatively address functional and molecular aspects of the involvement of PLD-derived phosphatidic acid (PA) in regulated exocytosis and as PLD1 inhibitor to treat the knockout mice to study its effects on them.

Biochem/physiol Actions

VU0359595 helps to block phospholipase D (PLD) which in turn reduces deoxyribonucleoside triphosphate (dNTP) biosynthesis in glioma models.

Packaging

5 mL Amber Glass Screw Cap Vial (857371P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable