19-148

Bafilomycin A1

• Synonym(s): Bafilomycin A
• UNSPSC Code: 12352106
• eCl@ss: 32160405
• NACRES: NA.41

Properties

• description: Bafilomycin A1 is a specific potent inhibitor of vacuolar-type H+-ATPases, and blocks lysosomal cholesterol transport in macrophages.
• Quality Level: 100
• manufacturer/tradename: Upstate^®
• technique(s): activity assay: suitable (kinase)
• storage temp.: −20°C

Description

Application

Bafilomycin A1 has been used:

• as an autophagy inhibitor to study its effect on traumatic brain injury (TBI)-induced cell death and lesions in mice
• to treat neurons for pH luorin assays to measure endocytosis during synaptic activity
• to block autophagy in mouse embryonic fibroblasts

Biochem/physiol Actions

Inhibitor Type: Kinase

Physical form

C₃₅H₅₈O₉

Storage and Stability

3 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3