475880

ML-7, Hydrochloride

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (K_i = 300 nM).

• Synonym(s): ML-7, Hydrochloride, 1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl
• Empirical Formula (Hill Notation): C₁₅H₁₇IN₂O₂S · xHCl
• CAS Number: 110448-33-4
• Molecular Weight: 416.28 (free base basis)
• MDL number: MFCD00065524
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: >98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubility: 50% ethanol: 4.5 mg/mL; DMSO: 4.5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: Ic1c2c(c(ccc2)[S](=O)(=O)N3CCNCCC3)ccc1
• InChI: 1S/C15H17IN2O2S/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18/h1-2,4-7,17H,3,8-11H2
• InChI key: GEHJIACZUFWBTK-UHFFFAOYSA-N

Description

General description

A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (K_i = 300 nM). Inhibits protein kinase A (K_i = 21 µM)and protein kinase C (K_i = 42 µM) at much higher concentrations.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Myosin light chain kinase (Mlck)

Product competes with ATP.

Reversible: yes

Target K_i: 300 nM against myosin light chain kinase

Warning

Toxicity: Standard Handling (A)

Preparation Note

Further dilute with aqueous buffer just prior to use.

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Other Notes

Krarup, T., et al. 1998. Am. J. Physiol. 275, C239.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable