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5.09612

Sigma-Aldrich

TAPI-2

InSolution, ≥97%, 10 mM aqueous solution, inhibitor of matrix metalloproteinases and TACE (TNF-α convertase; ADAM17)

Synonym(s):

InSolution TAPI-2

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10 MG
$1,600.00

About This Item

Empirical Formula (Hill Notation):
C19H37N5O5
CAS Number:
187034-31-7
Molecular Weight:
415.53
MDL number:
MFCD00040626
UNSPSC Code:
12352200
NACRES:
NA.77

$1,600.00

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Quality Level

100

Assay

≥97% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

storage temp.

−70°C

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This Item
579052579053529576
TAPI-2 InSolution, ≥97%, 10 mM aqueous solution, inhibitor of matrix metalloproteinases and TACE (TNF-α convertase; ADAM17)

5.09612

TAPI-2

TAPI-2 TAPI-2, CAS 187034-31-7, is a hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes.

579052

TAPI-2

TAPI-1 InSolution, ≥97%, inhibits MMPs and TACE

579053

TAPI-1

PP2 InSolution, ≥95%, 10 mM, reversible ATP-competitive inhibitor of the Src family of protein tyrosine kinases

529576

PP2

form

liquid

form

solid

form

liquid

form

liquid

assay

≥97% (HPLC)

assay

≥97% (HPLC)

assay

≥97% (HPLC)

assay

≥95% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, protect from light

General description

A hydroxamate-based inhibitor of matrix metalloproteinases and TACE (TNF-α convertase; ADAM17). Inhibits the activation-dependent shedding of L-selectin from neutrophils, eosinophils, and lymphocytes as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also blocks the shedding of several cell surface proteins such as pro-TGF-α, IL-6 receptor α-subunit, and β-amyloid precursor protein. Reported to inhibit TNF-α release and impart protection against aspirin-induced gastric mucosal injury. Acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µM).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Physical form

A 10 mM (1 mg/241 µL) sterile-filtered solution of TAPI-2 (Cat. No. 579052) in H₂O.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C.

Other Notes

Bennett, T.A., et al. 2000. J. Immunol.164, 4120.
Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther.12, 1139.
Hooper, N.M., et al. 1997. Biochem. J.321, 265.
Parvathy, S., et al. 1997. Biochem. J.327, 37.
Arribas, J., et al. 1996. J. Biol. Chem.271, 11376.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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