MAB1681

Anti-Vimentin Antibody

CHEMICON^®, mouse monoclonal, LN-6

• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• Product Name: Anti-Vimentin Antibody, clone LN-6, culture supernatant, clone LN-6, Chemicon^®
• biological source: mouse
• Quality Level: 100
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: LN-6, monoclonal
• species reactivity: human, mouse
• manufacturer/tradename: Chemicon^®
• technique(s): immunohistochemistry: suitable (paraffin)
• isotype: IgM
• NCBI accession no.: NM_003380.2
• UniProt accession no.: P08670
• shipped in: dry ice
• target post-translational modification: unmodified
• Gene Information: human ... VIM(7431)

Description

General description

Vimentin is a class III intermediate filament protein (homopolymers) found in various non-epithelial cells including mesenchymal cells and fibroblasts. In many cells of mesenchymal origin, it is one of the most prominent phosphoproteins, especially during cell division when enhanced phosphorylation of vimentin corresponds with the reorganization of vimentin filaments.

Specificity

Reacts with human mesenchymal cells and derived sarcomas. Reacts with an epitope of the cytoskeletal protein vimentin but unlike other vimentin antibodies, does not react with human lymphoid cells or derived malignancies. Reactive with endothelium, muscle, fibroblasts, melanocytes, peripheral nerve, sertoli cells, kidney mesangial cells and tubules, osteoblasts and periosteum, non-hematopoietic tumors of mesenchymal origin (all sarcomas), meningiomas and melanomas.

Immunogen

Nuclei from adult human thymic biopsy specimens.

Application

Anti-Vimentin Antibody, clone LN-6 detects level of Vimentin & has been published & validated for use in IH(P).

Immunohistochemistry on B5 fixed, paraffin embedded tissue sections.

Target description

57-60 kDa

Physical form

Liquid tissue culture supernatant containing 0.02% sodium azide.

Analysis Note

Control
Hyperplastic lymph nodes.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable