293105

Tetrahydropyran

anhydrous, 99%

• Synonym(s): Pentamethylene oxide
• Empirical Formula (Hill Notation): C₅H₁₀O
• CAS Number: 142-68-7
• Molecular Weight: 86.13
• Beilstein: 102436
• EC Number: 205-552-8
• MDL number: MFCD00006585
• UNSPSC Code: 12352005
• PubChem Substance ID: 57648359
• NACRES: NA.21
• grade: anhydrous
• bp: 88 °C (lit.)

Properties

• grade: anhydrous
• Quality Level: 100
• vapor density: 3 (vs air)
• Assay: 99%
• form: liquid
• impurities: <0.003% water; <0.005% water (100 mL pkg)
• evapn. residue: <0.0003%
• refractive index: n20/D 1.42 (lit.)
• bp: 88 °C (lit.)
• mp: −45 °C (lit.)
• density: 0.881 g/mL at 25 °C (lit.)
• SMILES string: C1CCOCC1
• InChI: 1S/C5H10O/c1-2-4-6-5-3-1/h1-5H2
• InChI key: DHXVGJBLRPWPCS-UHFFFAOYSA-N

Description

General description

Tetrahydropyran (THP) is a saturated cyclic ether. It is commonly used as a solvent in organic synthesis because of its strong hydrophobicity and low vaporization temperature, which enable easy recovery and reuse of the solvent. This makes the entire synthetic process more environmentally friendly.

Application

Tetrahydropyran can be used as a solvent in various classical organic reactions such as radical reactions, palladium-catalyzed coupling, and Grignard reactions.

Safety Information

• Pictograms: GHS02
• Signal Word: Danger
• Hazard Statements: H225
• Precautionary Statements: P210 - P233 - P240 - P241 - P242 - P243
• Hazard Classifications: Flam. Liq. 2
• Supplementary Hazards: EUH019
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 3.2 °F - closed cup
• Flash Point(C): -16 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves