318604

Ammonium chloride-ammonium hydroxide buffer solution

in H₂O

• Synonym(s): Ammonium Buffer Solution
• MDL number: MFCD00134124
• UNSPSC Code: 12161705
• PubChem Substance ID: 329753929
• NACRES: NA.21

Properties

• form: liquid
• Quality Level: 100
• composition: NH₄Cl, 1 wt. % ; NH₄OH, 4 wt. % (pH 10 to 11)
• concentration: in H₂O
• pH: 10-11
• density: 0.99 g/mL at 25 °C
• SMILES string: N.N.O.Cl
• InChI: 1S/ClH.2H3N.H2O/h1H;2*1H3;1H2
• InChI key: XEXFVRMLYUDDJY-UHFFFAOYSA-N

Description

Application

Ammonium chloride-ammonium hydroxide buffer solution may be used to crystallize proteins.

Biochem/physiol Actions

Ammonium chloride is the salt component of ammonium chloride-ammonium hydroxide buffer system that completely inhibits the BVDV infection of MDBK cells when present at a concentration of 50 mM .[1] Viruses treated with ammonium chloride (NH₄Cl) results in loss of infectivity because it neutralizes the pH of endosome. Hence, viruses with low pH-dependent fusion activity became incapable to fuse their envelope with endosomal membrane.[2]

Safety Information

• Pictograms: GHS05,GHS09
• Signal Word: Danger
• Hazard Statements: H315,H318,H410
• Precautionary Statements: P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable