63174

4-Maleimidobutyric acid

≥98.0% (T)

• Synonym(s): γ-Maleimidobutyric acid, 4-Maleimidobutanoic acid, N-(3-Carboxypropyl)maleimide, N-Maleoyl-4-aminobutyric acid, N-Maleoyl-GABA
• Empirical Formula (Hill Notation): C₈H₉NO₄
• CAS Number: 57078-98-5
• Molecular Weight: 183.16
• Beilstein: 1455876
• MDL number: MFCD00043139
• UNSPSC Code: 12352106
• PubChem Substance ID: 329759801
• NACRES: NA.25

Properties

• Quality Level: 100
• Assay: ≥98.0% (T)
• mp: 95-98 °C
• SMILES string: OC(=O)CCCN1C(=O)C=CC1=O
• InChI: 1S/C8H9NO4/c10-6-3-4-7(11)9(6)5-1-2-8(12)13/h3-4H,1-2,5H2,(H,12,13)
• InChI key: NCPQROHLJFARLL-UHFFFAOYSA-N

Description

Application

Gamma-maleimidobutyric acid may be used as a spacer in the construction of drug and other types of bioconjugates. 4-Maleimidobutyric acid is used with N-hydroxysuccinimide ester as a bifunctional cross-linking agent.

Modification reagent for thiol groups in proteins

Other Notes

SH-label for the modification of peptides and proteins; Used for the preparation of a new bleomycin analog for enzyme immunoassay (EIA); probe for membrane SH-groups

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves