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917133

Sigma-Aldrich

(4-(Piperidin-4-yl)phenyl)methanamine dihydrochloride

≥95%

Synonym(s):

Semi-flexible linker for PROTAC® development

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About This Item

Empirical Formula (Hill Notation):
C12H20Cl2N2
CAS Number:
2140866-85-7
Molecular Weight:
263.21
MDL number:
MFCD29075588
UNSPSC Code:
12352116
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Quality Level

100

Assay

≥95%

form

powder

reaction suitability

reagent type: linker

functional group

amine

storage temp.

2-8°C

SMILES string

NCC1=CC=C(C=C1)C2CCNCC2.Cl.Cl

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p-Xylene suitable for HPLC, ≥99%

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application(s)

pharmaceutical (small molecule)

application(s)

environmental

application(s)

food and beverages

application(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable

technique(s)

GC/MS: suitable

format

neat

format

neat

format

-

format

-

Quality Level

300

Quality Level

100

Quality Level

100

Quality Level

100

grade

certified reference material, pharmaceutical secondary standard

grade

analytical standard

grade

-

grade

-

storage temp.

2-30°C

storage temp.

-

storage temp.

-

storage temp.

-

Application

(4-(Piperidin-4-yl)phenyl)methanamine dihydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Storage Class Code

11 - Combustible Solids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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