D137510

N,N-Dimethylacetamide

ReagentPlus^®, 99%

• Linear Formula: CH₃CON(CH₃)₂
• CAS Number: 127-19-5
• Molecular Weight: 87.12
• Beilstein: 1737614
• EC Number: 204-826-4
• MDL number: MFCD00008686
• UNSPSC Code: 12352111
• PubChem Substance ID: 329798690
• NACRES: NA.21
• bp: 164.5-166 °C (lit.)
• vapor pressure: 2 mmHg ( 25 °C); 4 mmHg ( 38 °C)

Properties

• vapor density: 3 (vs air)
• Quality Level: 100
• vapor pressure: 2 mmHg ( 25 °C); 4 mmHg ( 38 °C)
• product line: ReagentPlus^®
• Assay: 99%
• form: liquid
• autoignition temp.: 914 °F
• expl. lim.: 1.8 %, 100 °F; 11.5 %, 160 °F
• dilution: (for general lab use)
• refractive index: n20/D 1.437 (lit.)
• pH: 4 (20 °C, 200 g/L)
• bp: 164.5-166 °C (lit.)
• mp: −20 °C (lit.)
• density: 0.937 g/mL at 25 °C (lit.)
• SMILES string: CN(C)C(C)=O
• InChI: 1S/C4H9NO/c1-4(6)5(2)3/h1-3H3
• InChI key: FXHOOIRPVKKKFG-UHFFFAOYSA-N

Description

General description

N,N-Dimethylacetamide (DMAc) is a water-miscible organic solvent used in the synthesis of styrene′s, vinyl resins, linear polyesters, acrylic fibers, plastics, pesticides, and synthetic leather. Additionally, it is utilized in the production of adhesives, films, and paint. It participates in dehydrogenation, dehydration, halogenation, deprotonation reactions and reductive carbonylation of transition metals. It can also act as catalysts, promoters, halogen/alkoxy or hydroxyl/halogen exchange mediators, reducing agents, and sources of the base.

Application

N,N-Dimethylacetamide can be used as a solvent in the synthesis of:

• Cellulose-HA (hydroxyapatite) nanocomposites using microcrystalline cellulose, CaCl₂, and NaH₂PO₄.
• 5-hydroxymethylfurfural (HMF) from various carbohydrates and natural biopolymer lignocellulose in the presence of LiCl. 

It can also be used:

• In the Pd-catalyzed regioselective synthesis of ketones from olefins using molecular oxygen.
• As a solvent as well as a methylene source in the regioselective linkage of two imidazo[1,2-a] pyridines using Cu(OAc)₂ catalyst.

Features and Benefits

N,N-Dimethylacetamide has

• High dissolution power of various substrate.
• High capacity to solvate anions.

Legal Information

Belle Chemical Company

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Danger
• Hazard Statements: H312 + H332,H319,H360D
• Precautionary Statements: P202 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 2
• Flash Point(F): 147.2 °F - closed cup
• Flash Point(C): 64 °C - closed cup