61760

Lectin from Canavalia ensiformis

lyophilized, ≥50% (GE), powder

• Synonym(s): Agglutinin from jack beans, Con A
• MDL number: MFCD00071069
• UNSPSC Code: 12352202
• NACRES: NA.56

Properties

• biological source: Canavalia ensiformis
• Quality Level: 100
• form: powder
• quality: lyophilized
• mol wt: M_r ~53000
• concentration: ≥50% (GE)
• technique(s): XRF: suitable
• storage temp.: 2-8°C

Description

Biochem/physiol Actions

Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca²⁺ and Mn²⁺ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable