A0637

DL-2-Aminoadipic acid

≥99% (TLC), powder, gliotoxic

• Synonym(s): DL-α-Aminoadipic acid
• Linear Formula: HO₂C(CH₂)₃CH(NH₂)CO₂H
• CAS Number: 542-32-5
• Molecular Weight: 161.16
• EC Number: 208-809-2
• MDL number: MFCD00063119
• UNSPSC Code: 12352106
• PubChem Substance ID: 24890441
• NACRES: NA.32

Properties

• Product Name: DL-2-Aminoadipic acid, ≥99%
• Quality Level: 200
• Assay: ≥99%
• form: powder
• mp: 196-198 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: NC(CCCC(O)=O)C(O)=O
• InChI: 1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)
• InChI key: OYIFNHCXNCRBQI-UHFFFAOYSA-N
• Gene Information: rat ... Grin2b(24410)

Description

Application

DL-2-Aminoadipic acid (AAA) has been used as an astrotoxin to kill astrocytes that prevent efficient integration of transplanted cells into the retina. It has also been used as a gliotoxin to study the effect of astrocytic swelling on the tortuosity.

Biochem/physiol Actions

DL-2-Aminoadipic acid (AAA) is a six-carbon homolog of glutamate and a gliotoxic compound. It is generally used to considerably reduce the number of astroglia in cerebellar cultures that acts as a model to study the mechanisms of a-aminoadipic acid induced glial toxicity.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H317
• Precautionary Statements: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable