A0781

Aphidicolin from Nigrospora sphaerica

≥98% (HPLC), powder

• Synonym(s): APC
• Empirical Formula (Hill Notation): C₂₀H₃₄O₄
• CAS Number: 38966-21-1
• Molecular Weight: 338.48
• Beilstein: 4689958
• MDL number: MFCD00083214
• UNSPSC Code: 12352200
• PubChem Substance ID: 57653817
• NACRES: NA.77

Properties

• Quality Level: 300
• Assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]27/D +12°, c = 1 in methanol(lit.)
• color: white
• mp: 227-233 °C (lit.)
• solubility: ethanol: 1 mg/mL (stable at least a week at 4°C.); DMSO: 10 mg/mL (stable at least six weeks at −20°C.); methanol: 10 mg/mL; H₂O: insoluble
• antibiotic activity spectrum: neoplastics; viruses
• Mode of action: DNA synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: [H][C@@]12CC[C@@]3([H])[C@](C)(CO)[C@H](O)CC[C@]3(C)[C@]14CC[C@](O)(CO)[C@]([H])(C2)C4
• InChI: 1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
• InChI key: NOFOAYPPHIUXJR-APNQCZIXSA-N
• Gene Information: human ... POLA1(5422), POLD1(5424), POLG(5428)

Description

Biochem/physiol Actions

Aphidicolin is an antibiotic, a potent antiviral and antimitotic agent and DNA polymerase inhibitor.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Caution

Estimated shelf-life is two years. For optimal stability, it should be protected from light and stored desiccated.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves