A1527

Adrenocorticotropic Hormone Fragment 7-38 human

≥97% (HPLC)

• Empirical Formula (Hill Notation): C₁₆₇H₂₅₇N₄₇O₄₆
• CAS Number: 68563-24-6
• Molecular Weight: 3659.11
• MDL number: MFCD00081282
• UNSPSC Code: 51111800
• NACRES: NA.77
• biological source: synthetic (organic)
• form: powder

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• sterility: non-sterile
• Assay: ≥97% (HPLC)
• form: powder
• UniProt accession no.: P01189
• storage temp.: −20°C
• Gene Information: human ... POMC(5443)

Description

Amino Acid Sequence

Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu

Application

Adrenocorticotropic hormone fragment 7-38 human has been used as astandard in external calibration for mass spectrometry.

Biochem/physiol Actions

Adrenocorticotropic hormone (ACTH) is a polypeptide hormone thatstimulates adrenocortical activity. It is produced by the prohormoneproopiomelanocortin (POMC), which is synthesized in the corticotroph andmelanotroph cells found in the intermediate and anterior lobe of the pituitarygland and the arcuate nucleus of the hypothalamus. ACTH is also synthesized inthe skin. It plays a role in controlling steroidogenesis in the adrenal glandand prevents reactive oxygen species (ROS)-induced cell toxicity. Higher levelsof ACTH lead to skin hyperpigmentation due to the hyperstimulation ofmelanocytes, characteristic of primary adrenal insufficiency (PAI). Deficiencyof ACTH synthesis, receptors, or signaling is associated with adrenalinsufficiency.

Other Notes

ACTH fragment that is a potent inhibitor of ACTH-stimulated adenylate cyclase.

Lyophilized from 0.1% TFA in H2O

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves