A3509

2-Aminopurine

≥99%

• Synonym(s): 2-AP
• Empirical Formula (Hill Notation): C₅H₅N₅
• CAS Number: 452-06-2
• Molecular Weight: 135.13
• EC Number: 207-197-4
• MDL number: MFCD00005566
• UNSPSC Code: 41106305
• PubChem Substance ID: 24890778
• NACRES: NA.51

Properties

• biological source: synthetic
• Quality Level: 200
• Assay: ≥99%
• form: powder
• mp: 280-282 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: Nc1ncc2[nH]cnc2n1
• InChI: 1S/C5H5N5/c6-5-7-1-3-4(10-5)9-2-8-3/h1-2H,(H3,6,7,8,9,10)
• InChI key: MWBWWFOAEOYUST-UHFFFAOYSA-N

Description

Application

2-Aminopurine (2-AP) is used to specifically inhibit double-stranded RNA-dependent protein kinase, protein kinase R (PKR).

2-Aminopurine has been used to inhibit eukaryotic initiation factor-2α (eIF2α)-phosphorylation of osteoarthritis (OA) chondrocytes.

Biochem/physiol Actions

2-Aminopurine (2AP) is an analog of guanosine and adenosine, which can base pair with cytosine and thymine. It is used as a fluorescent probe in nucleic acid structure and dynamics. 2-Aminopurine (2-AP) inhibits double-stranded RNA-dependent protein kinase, protein kinase R (PKR).

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves