A7154

Adenosine, periodate oxidized

≥93%

• Synonym(s): ADOX, Adenosine-2′,3′-dialdehyde
• Empirical Formula (Hill Notation): C₁₀H₁₁N₅O₄
• CAS Number: 34240-05-6
• Molecular Weight: 265.23
• MDL number: MFCD00056960
• UNSPSC Code: 41106305
• PubChem Substance ID: 24891180
• NACRES: NA.51

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• Assay: ≥93%
• form: powder
• solubility: 0.2 M HCl: 50 mg/mL, clear, colorless to faintly yellow
• storage temp.: −20°C
• SMILES string: Nc1ncnc2n(cnc12)C(OC(CO)C=O)C=O
• InChI: 1S/C10H11N5O4/c11-9-8-10(13-4-12-9)15(5-14-8)7(3-18)19-6(1-16)2-17/h1,3-7,17H,2H2,(H2,11,12,13)
• InChI key: ILMNSCQOSGKTNZ-UHFFFAOYSA-N

Description

Application

Adenosine, periodate oxidized has been used:

• as a methylarginine transferase inhibitor in the human embryonic kidney (HEK)-293 T cells
• as a methylase inhibitor in H4 neuroglioma
• as a broad inhibitor of S-adenosylmethionine (AdoMet)-dependent methyltransferases in mouse embryo fibroblast NIH3T3 cells

Biochem/physiol Actions

Adenosine, periodate oxidized (Adox) is a protein arginine methyltransferases (PRMTs) inhibitor. It also inhibits the enzyme S-adenosylhomocysteine hydrolase and induces apoptosis. Its inhibitory effect on histone methyltransferases prevents histone methylation. Adox also elicits intrinsic cytotoxic properties.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves