A8231
AGK2
≥97% (HPLC), powder
Synonym(s):
2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
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About This Item
Empirical Formula (Hill Notation):
C23H13Cl2N3O2
CAS Number:
Molecular Weight:
434.27
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥97% (HPLC)
form
powder
solubility
DMSO: 2 mg/mL, clear (warmed)
H2O: insoluble
storage temp.
room temp
SMILES string
Clc1ccc(Cl)c(c1)-c2ccc(\C=C(/C#N)C(=O)Nc3cccc4ncccc34)o2
InChI
1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+
InChI key
SVENPFFEMUOOGK-SDNWHVSQSA-N
Application
AGK2 is a SIRT2 inhibitor. AGK2 has been used in a study to determine that SIRT2 inhibition induces cell death and decreases the intracellular ATP level. AGK2 also rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.
Biochem/physiol Actions
AGK2 is a SIRT2 inhibitor. AGK2 rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models. IC50 for SIRT2 = 3.5 uM. AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRT3. AGK2 may be the most selective SIRT2 inhibitor available.
AGK2 is a SIRT2 inhibitor; rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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