C3635

4-Chloro-DL-phenylalanine methyl ester hydrochloride

• Linear Formula: ClC₆H₄CH₂CH(NH₂)CO₂CH₃·HCl
• CAS Number: 14173-40-1
• Molecular Weight: 250.12
• EC Number: 238-024-0
• MDL number: MFCD00012530
• UNSPSC Code: 12352209
• PubChem Substance ID: 24278310
• NACRES: NA.32

Properties

• form: powder
• Quality Level: 200
• mp: 186-189 °C (lit.)
• storage temp.: −20°C
• SMILES string: Cl.COC(=O)C(N)Cc1ccc(Cl)cc1
• InChI: 1S/C10H12ClNO2.ClH/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7;/h2-5,9H,6,12H2,1H3;1H
• InChI key: GCBCWTWQAFLKJG-UHFFFAOYSA-N
• Gene Information: human ... TPH1(7166), TPH2(121278)

Description

General description

4-Chloro-DL-phenylalanine methyl ester hydrochloride stimulates glucose intolerance in pregnant mice. Studies have shown that 4-Chloro-DL-phenylalanine methyl ester hydrochloride is associated with cognitive defects in rodents.

Application

4-Chloro-DL-phenylalanine methyl ester hydrochloride has been used to induce 5-hydroxytryptamine (5-HT) depletion in rats.

Biochem/physiol Actions

Tryptophan hydroxylase inhibitor.

Tryptophan hydroxylase inhibitor. Crosses blood brain barrier better than p−chlorophenylalanine.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves