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C3649

Sigma-Aldrich

CHAPSO

≥98%

Synonym(s):

3-([3-Cholamidopropyl]dimethylammonio)-2-hydroxy-1-propanesulfonate

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About This Item

Empirical Formula (Hill Notation):
C32H58N2O8S
CAS Number:
82473-24-3
Molecular Weight:
630.88
Beilstein:
5842642
MDL number:
MFCD00081079
UNSPSC Code:
12161900
PubChem Substance ID:
24892634
NACRES:
NA.25
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description

zwitterionic

Quality Level

200

Assay

≥98%

form

powder

mol wt

micellar avg mol wt 7000

aggregation number

11

technique(s)

protein quantification: suitable

conductivity

≤100 μmho per cm at 24 °C (0.5 M aqueous solution)

CMC

8 mM (20-25°C)

mp

184-186 °C (lit.)

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CHAPSO ≥98%

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CHAPSO Unique detergent with high CMC that solubilizes membrane-bound proteins in their native state.

220202

CHAPSO

assay

≥98%

assay

>98% (TLC)

assay

≥98.0% (TLC)

assay

>98% (TLC)

form

powder

form

powder

form

powder

form

solid

technique(s)

protein quantification: suitable

technique(s)

protein quantification: suitable

technique(s)

-

technique(s)

-

aggregation number

11

aggregation number

-

aggregation number

11

aggregation number

11

description

zwitterionic

description

-

description

zwitterionic

description

-

mol wt

micellar avg mol wt 7000

mol wt

630.88 g/mol

mol wt

micellar avg mol wt 7000

mol wt

micellar wt 9960

General description

CHAPSO is a non-denaturing zwitterionic bile salt derivative,[1] derived from Chaps by the addition of a functional hydroxyl group.

Application

A nondenaturing zwitterionic detergent with characteristics similar to CHAPS, although it is more soluble due to a more polar head group. Useful for the solubilization of integral membrane proteins.
CHAPSO has been used:
  • in a study to assess the processes of liposome solubilization and reconstitution of two transport proteins[2]
  • in a study to investigate a novel bicelle system for orienting macromolecules over a wide temperature range[3]
  • as a mixture with dilauroyl phosphatidylcholine (DLPC) in solid-state nuclear magnetic resonance (NMR) technique to study membrane-associated proteins[4]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    SLBG1674V
    SLBD5164V
    116K5304
    056K5317
    056K5300

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    A liquid crystalline medium for measuring residual dipolar couplings over a wide range of temperatures.
    Wang H, et al.
    Journal of Biomolecular Nmr, 12(3), 443-446 (1998)
    J Cladera et al.
    European journal of biochemistry, 243(3), 798-804 (1997-02-01)
    The process of liposome solubilization and reconstitution of two transport proteins have been studied using Chaps and Chapso (3-[(3-cholamidopropyl)dimethylammonio]-2- hydroxy-1-propanesulfonate). The solubilization of unilamellar liposomes was followed by absorption experiments and the process was shown to fit well to the
    S Cavagnero et al.
    Journal of biomolecular NMR, 13(4), 387-391 (1999-06-03)
    We have prepared and characterized a novel bicelle system composed of 1,2-di-O-dodecyl-sn-glycero-3-phosphocholine (DIODPC) and 3-(chloramidopropyl)dimethylammonio-2-hydroxyl-1-propane sulfonate (CHAPSO). At the optimal DIODPC/CHAPSO molar ratio of 4.3:1, this medium becomes magnetically oriented from pH 6.5 down to pH 1.0. Unlike previously reported
    Magnetically orientable phospholipid bilayers containing small amounts of a bile salt analogue, CHAPSO.
    Sanders CR and Prestegard J
    Biophysical Journal, 58(2), 447-460 (1990)
    M D Womack et al.
    Biochimica et biophysica acta, 733(2), 210-215 (1983-09-07)
    Over 50 detergents were tested to establish which would be most effective in releasing proteins from membrane-bounded compartments without denaturing them. Various concentrations each of detergent were tested for two activities: (1) solubilization of egg phospholipid liposomes as measured by
    View All Related Papers

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