C5424

Conduritol B epoxide

powder, ≥95% (TLC)

• Synonym(s): 1,2-Anhydro-myo-inositol
• CAS Number: 6090-95-5
• MDL number: MFCD00077326
• UNSPSC Code: 12352119
• PubChem Substance ID: 24892783
• NACRES: NA.32

Properties

• Product Name: Conduritol B epoxide,
• biological source: synthetic (organic)
• Quality Level: 100
• Assay: ≥95% (TLC)
• form: powder
• solubility: water: 20 mg/mL, clear, colorless to faintly yellow
• storage temp.: 2-8°C
• SMILES string: OC1C(O)C(O)C2OC2C1O
• InChI: 1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H
• InChI key: ZHMWOVGZCINIHW-UHFFFAOYSA-N

Description

General description

Conduritol B epoxide (CBE) is a mix of 1-L-1,2-anhydro-myo-inositol and 1-D-1,2-anhydro-myo-inositol.

Application

Conduritol B epoxide has been used as an inhibitor of GBA1 to discriminate between acid β-glucosidase (GBA1) and non-lysosomal β-glucosidase (GBA2) activity in β-glucosidase activity assay. It has also been used as a selective glucocerebrosidase (GCase) inhibitor.

Biochem/physiol Actions

β-Glucosidase inhibitor

Conduritol B epoxide (CBE) is capable of inactivating sucrase-isomaltase irreversibly. It can be used to produce cell and animal models to study on Gaucher disease (GD) and Parkinson′s disease (PD).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves