D4010

2′-Deoxyguanosine 5′-triphosphate sodium salt hydrate

≥96% (HPLC)

• Synonym(s): 2′-deoxy-, 5′-triphosphate sodium salt, Guanosine, dGTP sodium salt hydrate
• Empirical Formula (Hill Notation): C₁₀H₁₆N₅O₁₃P₃ · xNa⁺ · yH₂O
• CAS Number: 18423-40-0
• Molecular Weight: 507.18 (anhydrous free acid basis)
• MDL number: MFCD01311036
• UNSPSC Code: 41106305
• PubChem Substance ID: 24893806
• NACRES: NA.51

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• Assay: ≥96% (HPLC)
• form: powder
• shipped in: dry ice
• storage temp.: −20°C

Description

Application

2′-Deoxyguanosine 5′-triphosphate sodium salt hydrate has been used:

• as a component in a polymerase chain reaction (PCR) mixture for PCR product formation using AM-toxin primers
• as an internal standard to improve the analytical performance of capillary electrophoresis (CE) analysis for the evaluation of the cleanup process
• as a putative substrate in in vitro enzyme activity assay to incubate with nudix hydrolase 15 (NUDT15) protein for the evaluation of putative NUDT15 inhibitors

Biochem/physiol Actions

Deoxyguanosine 5′-triphosphate (dGTP), a purine deoxynucleotide, is a substrate of DNA polymerase(s) and reverse transcriptases. dGTP is useful to study the distribution, specificity, and kinetics of various nucleoside-triphosphatases (NTPase) and ribonucleotide reductases.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves