D4071

5, 15-DPP

• Synonym(s): 5,15-Diphenyl-21H,23H-porphine, 5,15-Diphenylporphyrin, 5,15-diphenyl-Porphine
• Empirical Formula (Hill Notation): C₃₂H₂₂N₄
• CAS Number: 22112-89-6
• Molecular Weight: 462.54
• MDL number: MFCD08276335
• UNSPSC Code: 12352200
• PubChem Substance ID: 329798793
• NACRES: NA.77

Properties

• form: powder
• Quality Level: 100
• SMILES string: c1ccc(cc1)-c2c3ccc(cc4ccc([nH]4)c(-c5ccccc5)c6ccc(cc7ccc2[nH]7)n6)n3
• InChI: 1S/C32H22N4/c1-3-7-21(8-4-1)31-27-15-11-23(33-27)19-25-13-17-29(35-25)32(22-9-5-2-6-10-22)30-18-14-26(36-30)20-24-12-16-28(31)34-24/h1-20,33,36H/b23-19-,24-20-,25-19-,26-20-,31-27-,31-28-,32-29-,32-30-
• InChI key: FNNOEKVUXXVPAI-DUVOQLPESA-N

Description

Application

5, 15-DPP has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:

• to analyze its effects on malignant peripheral nerve sheath tumor (MPNST) survival and proliferation
• to study its effects on the thymic stromal lymphopoietin (TSLP) modulation of nometastatic gene 23-H1 (NME1 or nm23-H1) expression in human trophoblasts
• to study its effects on 17β-estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced M2 polarization in human macrophages and endometrial stromal cells

Biochem/physiol Actions

5, 15-DPP is a selective STAT3 inhibitor and a selective STAT3-SH2 antagonist

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable